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The side effects of GIP/GLP-1 receptor agonists are most commonly gastrointestinal with nausea, vomiting, diarrhoea, constipation, but similar in severity and frequency to GLP-1 agonists [9]

This therapy obviously needs to be more investigated to avoid side effects in normal tissues but the combination of specific senescence markers to cytotoxic drugs is a potential promising therapy

The zero withdrawal rate in AOD-9604 trials suggests excellent practical tolerability that extends beyond merely counting adverse events to assessing their real impact on treatment continuation