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Patients with a body mass index (BMI) above 40 may experience more nausea during the lower titration steps, possibly because the weight-based drug exposure is relatively lower, creating a steeper pharmacodynamic curve when doses increase [11]

The company stated that no generic versions of semaglutide are currently available and described compounded alternatives as "unapproved fake or illegitimate knockoffs" that could "expose patients to serious safety and efficacy risks." As part of their effort to address this issue, Novo Nordisk has advocated for semaglutide to be added to the FDAs list of drugs that present "demonstrable difficulties for compounding." FDAs Decision and Timelines In February, the FDA declared that the semaglutide shortage was officially over

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Additionally, health care providers should be vigilant when prescribing and administering compounded semaglutide, as there may be different concentrations available