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Laron syndrome is a very informative experiment of nature and uncovers the link between low IIS and the related protection from diseases of civilization in contrast to exaggerated IIS induced by Western diet as shown in Figure 1

Critical for cell-based and in vitro assays

The GLS2 gene encoded glutaminase was originally thought to be liver specific but is in fact expressed in numerous tissues and is important in the glutamate-glutamine cycle in the brain

Key Research Applications Skin & collagen research: GHK-Cu and BPC-157 together support studies on collagen type I/III upregulation, elastin production, and dermal matrix integrity