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Previous AngIV analogs, while showing promise in animal models of dementia, were hindered by poor metabolic stability indicated by a short half-life, and an inability to cross the BBB due to their peptide nature

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The standard dosing schedule starts with 0.25 mg weekly for the first four weeks, increases to 0.5 mg weekly from weeks five through eight, and then may escalate to 1 mg or 2 mg weekly depending on tolerance and response

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