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Patients should expect that stopping retatrutide would result in similar weight regain trajectories to tirzepatide unless their lifestyle, nutrition, and exercise habits have changed substantially

doi: 10.1016/j.bbi.2024.05.006 171 AtkinsonEAGregoryHNCarterLNEvansRERobertonVHDickmanRet al

While the precise, overarching mechanism remains an active area of research, current understanding points to its ability to modulate fundamental biological processes crucial for healing, tissue regeneration, and maintaining cellular homeostasis

Second: moving to GLP-2(Tirz) when the research question involves GIP receptor contribution or when a larger effect magnitude is needed without introducing the glucagon receptor variable