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Metabolic/Bariatric Surgery (Third-Line) Indicated for BMI 40 or BMI 35 with obesity-related comorbidities (DM2, HTN, OSA, OA)

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the concept of well-defined subclasses of cells committed to express a specific subset of hormones independent of their location is currently untenable, thus detailed description of the topographical location of the cells needs to be implemented for future clarity (4)

Patients who reach 2.4 mg and do not experience adequate response typically benefit more from combined therapy or alternative medications than from further dose escalation