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The caution is that the glucagon arm also explains a couple of the reported real-world effects, like a sensation of running warmer or having more energy, and a small average rise in resting heart rate of a few beats per minute

The dopamine system does not differentiate between categories of reward

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There's also a subset of high-performance labs focused on longevity, mitochondrial efficiency, and cognitive-energy tradeoffs in relation to metabolic compounds