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17,499,500,501,502,503 Insulin resistance, a common occurrence in NASH patients, is a key driver of the diseases progression
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In a phase 2b trial, tirzepatide treatment was associated in a dose-dependent manner with decreased levels of apolipoprotein (apo) B, apoC-III, large triglyceride-rich lipoprotein particles, and small low-density lipoprotein particles, suggesting a shift towards a less atherogenic lipoprotein profile [77]
After three days, the dose is increased to 300mg per day (three 100mg tablets per day taken six hours apart)
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