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It is diagnosed according to the Canadian consensus criteria, at least 6 months after onset when the following symptoms are present: fatigue, post-exertional malaise with a recovery period of at least 24 h, sleep dysfunction, pain, at least two neurological/neurocognitive symptoms and at least two symptoms involving the autonomic, neuroendocrine or immune system [19]

It is present in every cell and plays a vital role in detoxification, immune support, and protection against oxidative stress

There was less certainty regarding the relative effects of the drugs to each other, particularly for outcomes beyond weight loss (e.g., cardiovascular outcomes), for which reason the institute judged the comparison between tirzepatide and semaglutide as promising but inconclusive (P/I)

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