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At the cellular level, an in vitro study exposed neural cells to oxidative stress and reported that Cerebrolysin upregulated brain-derived neurotrophic factor (BDNF) and Neuregulin 1, consistent with the neurotrophic-mimicry hypothesis (Anandan et al

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Tesamorelin, a more potent GHRH analog, has Phase 3 human trial data for visceral fat reduction in HIV-associated lipodystrophy, which provides some mechanistic validation for the class