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This leads to the concept of microglia being critically involved in the early steps of the disease and identified them as important potential therapeutic targets

Preclinical studies have shown that co-targeting ferroptosis and pyroptosis (e.g., GPX4 inhibitor + GSDMD activator) can overcome compensatory resistance by engaging complementary cell death mechanisms, amplifying DAMP release, and enhancing T cell infiltration (181)

It belongs to the class of Growth Hormone Secretagogues (GHS) and is used in medical and research contexts to elevate growth hormone production (1)