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Additionally, any drug development for PWS will need to address the complexities of the syndrome, which includes not only hyperphagia and obesity but also developmental issues, psychiatric conditions, and endocrine disorders

An additional study investigated the long-term effects of EGCG in rats fed a high-fat/high-sucrose diet (HFSD) for six weeks

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Future trials should prioritize sufficient duration ( 1218 months), include high-risk subgroups (e.g., older adults, frail individuals, patients with rapid or marked weight loss, or chronic comorbidities such as chronic kidney disease), and integrate nutritional and resistance training interventions