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Palmitoylethanolamide (PEA) has shown promise in relieving various types of pain, including pelvic pain associated with endometriosis in women

Major vault protein regulates class A scavenger receptor-mediated tumor necrosis factor-alpha synthesis and apoptosis in macrophages

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The infiltration of immune cells such as macrophages, neutrophils, mast cells, B cells, T cells, NKT cells within the adipose tissue, coupled with the overproduction of inflammatory mediators and adipokines (e.g., leptin and lipocalin), adipocyte-derived MCP-1 and hypertrophy of visceral adipocytes, leads to hypoxia, autophagy, and apoptosis (130)