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Potential Risks and Unknowns Because TB500 influences angiogenesis and cell proliferation , some researchers have raised theoretical concerns about: Promoting unwanted cell growth (e.g., in precancerous tissues) Interfering with natural inflammatory processes during healing Suppressing immune responses with long-term or high-dose use There is no conclusive evidence showing carcinogenicity, but as with any peptide that affects growth and regeneration, caution is warranted especially if theres a history of tumors or systemic disease