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The efficacy and safety profile of the DPP-4 inhibitors shows a favorable profile of the DPP-4 inhibitors especially for patients with renal impairment as well as elderly subjects with type-2-diabetes

285,286,287 The MAPK pathway is an important pathway related to UC, 288 and its inhibition reduces inflammation by downregulating the levels of proinflammatory cytokines

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29,30B VitaminsA deficiency in B6, B12 or B9 (folate) can cause elevatedhomocysteine, which is linked with hypothyroidism.Folic acid levels have been linked to levels of thyroidstimulating hormone (TSH)