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KW6002 prevented mtDNA release by inhibiting EPAC1/VDAC1 pathway- mediated opening of MPTP The cGAS-STING pathway is activated by the presence of cytosolic DNA, which originates from viral and bacterial sources or aberrantly released mitochondrial DNA 110 .Therefore, the mitochondrial morphology and ultrastructure were observed by TEM, indicating that HY exposure resulted in blurred mitochondrial cristae and a significant increase in the number of abnormal mitochondria

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But we started observation of patients from the date of NIRS