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The thiol couples are maintained in a reduced state in both compartments in order to protect against oxidative stress ( FIGURE 1 TABLE 1 Illustration of Diet-Induced Changes in the NAD/NADH Ratio in Rat Liver [data from Illustration of Mitochondrial ROS Production Reactive oxygen species is produced in the mitochondrial electron transport chain when ATP levels are sufficient and excess fuel generates elevated NADH

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Lancet 2006;368:1696-705.ArticlePubMed 8