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Understanding the Problem: In women with androgenetic alopecia, androgens like testosterone and DHT cause progressive damage to hair follicles: Androgens bind to receptors in scalp hair follicles This binding triggers follicle miniaturization follicles gradually shrink Miniaturized follicles produce thinner, shorter, weaker hair Over time, follicles may stop producing visible hair altogether This is why hair gradually becomes finer and thinner in female pattern hair loss How Spironolactone Intervenes: Step 1: Blocks Androgen Receptors Spironolactone acts as an androgen receptor antagonist it occupies the receptors that androgens would normally bind to, preventing them from triggering follicle miniaturization
The flexibility of active sites in enzymes is provided by glycine [5]
