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In general, the side chains and the backbone of stapled peptides are usually structurally constrained, stabilizing the peptide to a predetermined conformation, thereby reducing the entropy penalty associated with binding to molecular targets and significantly improving the binding affinity of the peptides, which is known as the prepayment of entropy costs bound up with the binding process

Despite these benefits, our findings also suggest an increased risk of ketosis in individuals with T1DM treated with GLP-1 RAs 26

While gallbladder-specific events cannot occur after cholecystectomy, biliary tract disease can still develop, so vigilance for symptoms like biliary-type pain or jaundice remains important