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GLP-1 agonists can restore spontaneous ovulation in women with insulin-resistant PCOS by correcting the hyperinsulinemic environment that suppresses normal follicle development

Mechanism of Action Melanogenesis Stimulation: Activation of MC1R stimulates the synthesis and release of eumelanin (the protective, dark pigment, typically black/brown), as opposed to pheomelanin (the red/yellow pigment)

Ahn, S.H., Zhiang, J., Kim, H., Chang, S., Shin, J., Kim, M., Lee, Y., Lee, J.H., Park, Y.R

If the monthly arm comes in materially lower, prescribers will treat monthly as a convenience option for a subset, not the default