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Peer review information Nature Chemical Biology thanks Ali Tavassoli and the other, anonymous reviewer(s) for their contribution to the peer review of this work

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De este estudio se analiz un subgrupo de 95 pacientes que tenan AGLP1 de base y se concluy que la adicin de canagliflozina 100 y 300 mg mejora la HbA1c 1 y 1.06%, respectivamente, el ndice de masa corporal y la presin arterial (7.1 y 2.6 mmHg, respectivamente) en comparacin con un grupo placebo

First, Alzheimers disease and other dementias are strongly linked to metabolic dysfunctionespecially insulin resistance in the brain, sometimes labeled type 3 diabetes. Second, a class of diabetes and weight-management medicines called GLP-1 receptor agonists (GLP-1 RAs) shows early but increasingly consistent signals that they may lower dementia risk in people with type 2 diabetes, and possibly slow specific biological changes of Alzheimers in small clinical trials