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Whilst science can provide the scaffolding, compassion must lay the foundation: it must understand that stockpiling pens happens out of fear, that clinicians are struggling to offer clarity in the face of incomplete evidence and that poor health system planning has meant that patients are bearing the costs

In addition to its direct effects on beta cells, GIP also leads to increased glucagon secretion, and indirectly results in increased insulin secretion via communication between the alpha and beta cells of the pancreas ( via complex mechanisms, including stimulation of somatostatin secretion, which inhibits glucagon secretion, and indirectly via stimulation of insulin production, which then inhibits glucagon release ( Figure 1 Incretin action plays a large role on post-prandial secretion of insulin, and may account for up to 70% of hormone release ( Both incretins have effects outside the pancreas

Betz WJ, Mao F, Smith CB

King Saudi Univ J Dent Sci 2013;4:536