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Moreover, in vitro tests often rely on free radicals that do not naturally occur in biological systems (e.g., DPPH, AAPH, and ABTS), raising doubts about the relevance of their results to in vivo conditions (Murphy et al., 2011)

NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus