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Based on human neutrophil renewal rates, DPP1 inhibition is estimated to require approximately 20 days to achieve maximum NSP inhibitory effects in humans ( Pharmacokinetic studies demonstrate that DPP1 inhibitors such as brensocatib and BI 1291583 can produce sustained and stable NSP inhibitory effects
This means they can penetrate the blood-brain (or blood-SCF) barrier and reach neurons directly, enabling the drug to exhibit organ-specific combined effects in the brain
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