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Downstream of AKT phosphorylation in the activation of -cell proliferation is Wnt signaling, a pathway established in cancer biology to be critical for cell proliferation and survival

Most GLP-1 medications are injected under the skin as little as once a week

Sideek et al., 2024)

The typical regimen involves: Loading dose for patients without neurological involvement : Hydroxocobalamin 1mg intramuscularly three times weekly for two weeks [13] [10] Loading dose for patients with neurological involvement : Hydroxocobalamin 1mg on alternate days until no further improvement, then Maintenance therapy : 1mg every two to three months (or every two months if neurological involvement) Lifelong maintenance therapy is necessary for irreversible causes such as pernicious anaemia or following gastric surgery