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The NOS evaluates studies based on three criteria: (1) selection of study groups (representativeness, ascertainment of exposure, and demonstration that the outcome was not present at baseline), (2) comparability of groups (control for confounding factors), and (3) assessment of outcome (adequacy of follow-up and blinding of outcome assessment)

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The more serious concern is a black box FDA warning around suicidal thoughts linked to the bupropion ingredient, particularly in younger adults under 24

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