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Not following these instructions can make Rybelsus less effective or more likely to cause side effects

Cancer Cell 23 , 93106 (2013)

45,46 In contrast, anorexigenic neurons suppress appetite by expressing proopiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) peptide

The clinical hold applies to all ongoing clinical studies under the IND, including the Phase III HERO trial (AVK-101-301) evaluating ARD-101 for the treatment of hyperphagia in patients with PWS