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Among the primary underlying causes of cataracts are oxidative stress and glycation of the delicate proteins that naturally maintain the lens in a state of crystalline clarity

& Kleyman, T

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Mechanistically, the peptide perturbs the FOXO4 interaction with p53, which selectively causes p53 nuclear exclusion and cell-intrinsic apoptosis (Figure 2, this novel senolytic did remove cells from the PDL9 chondrocytes, which was accompanied by significantly reduced levels of SA--gal staining