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Dose reduction or temporary pause If you experience consistent side effects that do not subside over time or become intolerable, your clinicians may reduce the dose of retatrutide or pause the treatment for some time

Patients planning surgery should discuss tirzepatide with their healthcare team, though recent guidance from the American Society of Anesthesiologists indicates most patients can continue GLP-1 receptor agonists perioperatively, with modifications only for those at high risk of gastrointestinal complications

tirzepatide once weekly for the treatment of obesity

The separate TRANSCEND-T2D Phase 3 program covers type 2 diabetes (TRANSCEND-T2D-1 reported topline results March 19, 2026)