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At low concentrations, curcumin primarily interacts with the polar heads of the outer membrane surface

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56 Our findings build on two previously reported PDAC-specific characteristics, namely, 1st RAS signaling driving glutamine metabolism for ROS homeostasis 22,50,51 and 2nd mitochondrial dependency upon genetic loss of the KRAS oncogene, 41 and connect them with a more generally described cancer cell state associated with therapy resistance, characterized by a dependence on lipid peroxidation defense pathways