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Next, if -arrestin level is low ( c 1), then the precursor complex of the internalization and degradation, i.e., can no longer be formed, and the EC 50 value is effectively written as Consequently, S ( c L , ) effectively devoid of downregulation is obtained as depicted in Fig

No organ toxicity, no carcinogenicity signals, no reproductive toxicity have been demonstrated in animal models to date

P values indicated, determined by two-tailed t -test ( a ) or one-way ANOVA with Dunnetts multiple comparisons test against CTRL ( b )

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