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GLP-1 medications can cause fatigue through several mechanisms including reduced caloric intake due to appetite suppression, gastrointestinal side effects leading to dehydration and electrolyte imbalances, and metabolic adjustment to improved blood glucose control

Even minor temperature fluctuations or improper handling can cause the medication to degrade, reducing its ability to support weight loss and blood sugar control

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Nerve injuries: In sciatic nerve transection models, early axonal sprouting is detectable histologically within the first 714 days (Gjurasin et al., 2010)