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This data is valuable because it captures effects in broader populations than clinical trials, including people with comorbidities, those taking multiple medications, and those using doses or schedules that differ from trial protocols

Efficacy and safety of intranasal esketamine adjunctive to oral antidepressant therapy in treatment-resistant depression: a randomized clinical trial

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In this study, researchers collected public Facebook posts from U.S.-based users between 2022 and 2024 that mentioned GLP-1 RA medications, limiting their search to posts in English and pages administered in the U.S., and excluding posts from Facebook groups