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The study was based only on data from the published literature, did not allow for prospective or randomized controlled trials, and did not explore the direct associations between drug penetration ratios and adverse fetal or neonatal outcomes

Several factors influence how quickly results appear

94,292,328330 However, when hypoxia is prolonged, there is an up-regulation of natural antisense HIF-1 that decreases HIF-1 expression by destabilizing its mRNA

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