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haematobium GST (Sh28GST) has been shown to be well tolerated in Phase I and II clinical trials, and demonstrated the ability to block transmission of the parasite (Capron et al ., 2001)

3,6 Supplementation makes most sense when intake is likely to be low

[DOI] [PMC free article] [PubMed] [Google Scholar] 63.Caruso I., Marrano N., Biondi G., Genchi V.A., DOria R., Sorice G.P., Perrini S., Cignarelli A., Natalicchio A., Laviola L., et al

Pre-Blend Weekly Schedule Example Pre-blend dose at each titration step Phase Start Weeks 1-4 Draw Volume 0.40 mL (40 units) Reta Delivered 2.0 mg Cag Delivered 0.4 mg Phase Step 1 Weeks 5-8 Draw Volume 0.60 mL (60 units) Reta Delivered 3.0 mg Cag Delivered 0.6 mg Phase Step 2 Weeks 9-16 Draw Volume 0.80 mL (80 units) Reta Delivered 4.0 mg Cag Delivered 0.8 mg Phase Step 3 Weeks 17-20 Draw Volume 1.20 mL (120 units) Reta Delivered 6.0 mg Cag Delivered 1.2 mg Phase Step 4 Weeks 21-24 Draw Volume 1.60 mL (160 units) Reta Delivered 8.0 mg Cag Delivered 1.6 mg Phase Maintenance Weeks 25+ Draw Volume 2.40 mL (240 units) Reta Delivered 12.0 mg Cag Delivered 2.4 mg One injection per week