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In short, they are reported to increase the growth of intestinal epithelial cells, enhance intestinal barrier function, influence immune cell development and populations in the gut-associated lymphoid tissue, exert anti-inflammatory and potentially T H 1 promoting and/or T H 2 inhibiting effects on various intestinal immune cells, and modify the abundance of gut microbiota that might play a role in allergic sensitization (Figure 1)

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It also activates the FAK-paxillin signaling pathway in tendon fibroblasts, promoting cytoskeletal reorganization and directed cell migration both essential steps in connective tissue repair

( C ) Mean relative PPP Flux in A549shNRF2-BIND-luc cells treated with water (Control) or 2.5 ng/mL doxycycline (Dox) for 48 h and labeled with [1,2- 13 C]-glucose for 14.5 h