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Strategies to enhance N-methyl-D-aspartate receptor-mediated neurotransmission in schizophrenia, a critical review and meta-analysis

The activation of the classical cAMP pathway is achieved by releasing irritating G protein subunit Gs through the exchange of guanine nucleotide and the activation/dissociation of heterogeneous trimer G protein, and in pancreatic cells, GLP-1 binds to the specific guanine nucleotide-binding protein-coupled receptor GLP-1R, leading to adenylyl cyclase activation and elevated cAMP levels (Mayo et al., 2003

doi: 10.3389/fvets.2021.621732 Received 26 October 2020 Accepted 25 January 2021 Published 18 February 2021 Volume 8 - 2021 Edited by Nora Mestorino, National University of La Plata, Argentina Reviewed by Pieter Annaert, KU Leuven, Belgium