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Case studies published to date are mostly based on short-term, first trimester exposure with doxycycline

(2) Activation of the AGERAGE pathway induces ROS generation, which, in combination with mitochondrial dysfunction under diabetic conditions, exacerbates myocardial injury, further accelerates atrial remodeling, and promotes AF development (57, 58)

Apart from the pancreas, GLP-1R is also expressed in tissues such as gastrointestinal tract, central nervous system and reproductive system [44, 45]