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The key clinical, translational, perioperative, economic, and implementation-related evidence informing this proposed framework is summarized and critically appraised in Table 1, which also distinguishes direct human KOA evidence from indirect, observational, and hypothesis-generating evidence

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More information exist about GLP-1 analogs (as exendine-4) and their efficacy in controlling the evolution of NAFLD

Treatment goals: Jardiance provides modest weight loss with added heart and kidney benefits, while Ozempic and Wegovy typically lead to more substantial long-term weight loss