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Research into predictive biomarkers could improve patient selection and treatment monitoring

Primary Handling Editor: Sonia Muliyil, in collaboration with the Nature Medicine team

Conclusion: FOXO4-DRI promotes the nuclear export of phosphorylated P53 by inhibiting the binding of FOXO4 to P53 in endothelial cells, thereby facilitating the apoptosis of senescent endothelial cells and alleviating aging

PMID: 23259598 Bassi MT, Gasol E, Manzoni M, Pineda M, Riboni M, Martin R, Zorzano A, Borsani G, Palacin M (2001) Identification and characterisation of human xCT that co-expresses, with 4 F2 heavy chain, the amino acid transport activity system x c