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Combining these agents poses unpredictable risks to glucose metabolism, as tesamorelin raises GH and can induce insulin resistance, potentially opposing retatrutide's glycaemic effects

As a reminder, Zepbound's label [uspl.lilly.com] contains a boxed warning regarding potential risk of thyroid C-cell tumors and is contraindicated in patients with a personal or family history of MTC or in patients with multiple endocrine neoplasia syndrome type 2

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Only ~30 humans formally studied in all published literature