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CAFs targeted ultrasound-responsive nanodroplets loaded V9302 and GLULsiRNA to inhibit melanoma growth via glutamine metabolic reprogramming and tumor microenvironment remodeling

FIGURE 3 3.3 Nitazoxanide reduced inflammation in rats with MTX-hepatotoxicity A profound hepatic inflammation was observed in the MTX group, as demonstrated by significant augmentation in hepatic TNF-, IL-1, and IL-6 versus the CTRL group (Figures 4AC)