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Your stomach feels uncomfortably full because food is sitting there longer than usual

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The brain pathway may be more significant than the endocrine route for the physiological effects of GLP-1, especially regarding insulin release, but the endocrine route becomes more pronounced with bigger meals and more L-cell activation (Deacon 2019)

Graphical abstract Access this article Similar content being viewed by others Data Availability The data that support the findings of this study are available on request from the corresponding authors