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Symptoms include: Diarrhea (typically watery but not bloody) Low-grade fever Nausea Occasional muscle aches or headache Stomach cramps and pain Vomiting The vomiting and diarrhea are the largest concerns, as patients can quickly become dehydrated

As new treatment modalities emerge, clinicians must be equipped to navigate patient conversations about options, expectations, and adherence strategies

Retatrutide is an investigational triple-agonist (GLP-1, GIP, and glucagon) with a half-life of roughly 6 days (Coskun et al., Cell Metabolism, 2022)