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Foundayo (Orforglipron) The newest addition to weight loss medications is Foundayo, a daily GLP-1 pill offering flexibility without food or water restrictions

As a GLP-1 receptor agonist, it works by mimicking the natural incretin hormone GLP-1 to increase insulin secretion in a glucose-dependent manner, suppress glucagon release, slow gastric emptying by approximately 35%, and reduce appetite through central nervous system signaling

Particularly beneficial for individuals with a higher body fat percentage, it works by mimicking multiple naturally occurring hormones to aid in promoting satiety (the sensation of feeling full after eating) and achieving weight loss

This is associated with elevated release of inflammatory cytokines