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Second, since the majority of research on the pathophysiological role of UA in CVD was obtained from experimental studies, which were extrapolated to humans, more human studies should be performed to delineate the underlying mechanisms of the UA involvement in the pathophysiology of CVD

Jacobson A, Yang D, Vella M, Chiu IM

Because the goal is local gut exposure, the oral route is most often selected specifically when the gut is the target rather than as a substitute for systemic delivery

Dihexa or its analogs were administered 5 minutes after scopolamine, either intracerebroventricularly at doses of 0.1 or 1 nmol), intraperitoneally at doses of 0.05, 0.25, or 0.50 mg/kg, or orally at doses of 1.25 or 2.0 mg/kg