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Reconstitution is required since AOD 9604 typically comes as a lyophilized powder that must be mixed with bacteriostatic water before injection

Therefore, path 1 involving two successive [2,3]-sigmatropic rearrangements is mainly responsible for the two para -selective amination reactions (for details see Supplementary Figs 211 and Supplementary Data 1)

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While fertility treatment often focuses on the female partner, assessing male fertility is just as important in understanding why a couple may be struggling to conceive