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As a result of impaired blood supply, essential nutrients such as glucose and oxygen fail to adequately reach the ischemic core and surrounding region known as the penumbra

NAD + depletion elevates the methylation of BDNF promoter, triggering the dissociation of the DNA methylation-sensitive nuclear factor CCCTC-binding factor (CTCF) and cohesin from the BDNF locus

REFMAC5 dictionary: organization of prior chemical knowledge and guidelines for its use