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Medical and Health Benefits FDA-Approved Use Treatment of Methemoglobinemia: Methylene blue restores the oxygen-carrying capacity of red blood cells by converting methemoglobin back to hemoglobin

Johansson B, Dunwiddie LHTV, Masino SA, Poelchen W, Gimnez-Llort L, Escorihuela RM, Fernndez-Teruel A, Wiesenfeld-Hallin Z, Xu XJ, Hrdemark A, Betsholtz C, Herlenius E, Fredholm BB (2001) Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor

Alcohol irritates the stomach lining and can intensify these symptoms, making the adjustment period significantly more uncomfortable

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