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Chromosome analysis (including karyotype with fluorescence in-situ hybridization, FISH and array-comparative genomic hybridization, aCGH) is the first step of genetic analyses [136, 137]

The seminal studies of glycemic control have shown that metabolic memory or legacy effect of early control can prevent or delay the development of diabetic autonomic neuropathy and other complications [10, 11, 13, 144]